Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3.

doi:10.1007/s00125-013-2829-9

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3.

Diabetologia - 1 Apr 2013

Lallukka S, Sevastianova K, Perttilä J, Hakkarainen A, Orho-Melander M, Lundbom N, Olkkonen V M, Yki-Järvinen H

Abstract excerpt

AIMS/HYPOTHESIS: The rs738409 C>G single-nucleotide polymorphism in PNPLA3 leads to a missense mutation (I148M) which increases liver fat but does not cause insulin resistance. We hypothesised that patients with non-alcoholic fatty liver disease (NAFLD) due to the PNPLA3 variant ('PNPLA3 NAFLD' = PNPLA3-148MM) do not have adipose tissue (AT) inflammation in contrast with those with NAFLD due to obesity ('obese...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adiponectin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adipose Tissue

Share to Body Composition

Share to Fatty Liver

Share to Lipase

Share to Liver

Share to Non-alcoholic Fatty Liver Disease

Share to Obesity

Source

Open in PubMed

Identifiers

PMID: 23334462
DOI: 10.1007/s00125-013-2829-9

Genes

PNPLA3
ADIPOQ

Variants

rs738409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3.PMID 23334462Read ↗

Association of genetic variations with NAFLD in lean individuals.Semantic proximity Read ↗

Healthy PNPLA3 risk allele carriers present with unexpected body fat composition. A study of one thousand subjects.Semantic proximity Read ↗

Could inherited predisposition drive non-obese fatty liver disease? Results from German tertiary referral centers.Semantic proximity Read ↗

I148M variant in PNPLA3 reduces central adiposity and metabolic disease risks while increasing nonalcoholic fatty liver disease.Semantic proximity Read ↗

I148M variant of PNPLA3 increases the susceptibility to non-alcoholic fatty liver disease caused by obesity and metabolic disorders.Semantic proximity Read ↗

PNPLA3 I148M Polymorphism in Patients with Nonalcoholic Fatty Liver Disease, Obesity and Prediabetes.Semantic proximity Read ↗

Insulin resistance is an integral feature of MASLD even in the presence of PNPLA3 variantsSemantic proximity Read ↗

The I148M PNPLA3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls.Semantic proximity Read ↗

Non-alcoholic fatty liver disease, metabolic syndrome and patatin-like phospholipase domain-containing protein3 gene variants.Semantic proximity Read ↗

The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue.Semantic proximity Read ↗

Liver and Cardiovascular Damage in Patients With Lean Nonalcoholic Fatty Liver Disease, and Association With Visceral Obesity.Semantic proximity Read ↗

PNPLA3 rs738409 underlies treatment response in nonalcoholic fatty liver diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.