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Article

The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells.

Development (Cambridge, England) - 1 Oct 2010

Fernandez-Diaz Luis C, Laurent Audrey, Girasoli Sara, Turco Margherita, Longobardi Elena, Iotti Giorgio, Jenkins Nancy A, Fiorenza Maria Teresa, Copeland Neal G, Blasi Francesco

Abstract excerpt

Disruption of mouse Prep1, which codes for a homeodomain transcription factor, leads to embryonic lethality during post-implantation stages. Prep1(-/-) embryos stop developing after implantation and before anterior visceral endoderm (AVE) formation. In Prep1(-/-) embryos at E6.5 (onset of gastrulation), the AVE is absent and the proliferating extra-embryonic ectoderm and epiblast, marked by Bmp4 and Oct4,...

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Identifiers

PMID: 20826531
DOI: 10.1242/dev.050567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells.PMID 20826531Read ↗

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