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Article

Drugs targeting Bcl-2 family members as an emerging strategy in cancer

1 Sept 2010

Abstract excerpt

Inhibiting apoptosis is widely accepted as a necessary step in the transition from normal to cancer cells, and most cancer therapies exert their effects by indirectly reversing this process. Commitment to apoptosis is caused by permeabilisation of the outer mitochondrial membrane--a process regulated by the binding between different members of the Bcl-2 family. Furthermore, Bcl-2 family members also bind to the...

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PMID: 20822554
DOI: 10.1017/s1462399410001572

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