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Article

An independent, replicable, functional and significant risk variant block at intron 3 of CACNA1C for schizophrenia.

The Australian and New Zealand journal of psychiatry - 1 Apr 2022

Wang Zuxing, Chen Wenzhong, Cao Yuping, Dou Yikai, Fu Yingmei, Zhang Yong, Luo Xingqun, Kang Longli, Liu Na, Shi Yun Stone, Li Chiang-Shan R, Xu Yifeng, Guo Xiaoyun, Luo Xingguang

Abstract excerpt

OBJECTIVES: Genome-wide association studies have identified a significant risk gene, CACNA1C, for schizophrenia. In this study, we comprehensively investigated a large set of CACNA1C single-nucleotide polymorphisms (SNPs) to identify the replicable risk alleles for schizophrenia and explore their biological functions. METHODS: One Jewish (1044 cases vs 2052 controls), one European (1350 cases vs 1378 controls)...

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PMID: 33938268
DOI: 10.1177/00048674211009595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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