Article
A novel risk variant block across introns 36-45 of CACNA1C for schizophrenia: a cohort-wise replication and cerebral region-wide validation study.
Psychiatric genetics - 1 Oct 2023
Guo Xiaoyun, Wang Shibin, Lin Xiandong, Wang Zuxing, Dou Yikai, Cao Yuping, Zhang Yong, Luo Xinqun, Kang Longli, Yu Ting, Wang Zhiren, Tan Yunlong, Gao Shenshen, Zheng Hangxiao, Zhao Fen, Wang Huifen, Wang Kesheng, Xie Fan, Chen Wenzhong, Luo Xingguang
Abstract excerpt
OBJECTIVES: Numerous genome-wide association studies have identified CACNA1C as one of the top risk genes for schizophrenia. As a necessary post-genome-wide association study (GWAS) follow-up, here, we focused on this risk gene, carefully investigated its novel risk variants for schizophrenia, and explored their potential functions. METHODS: We analyzed four independent samples (including three European and one...
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