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Article

Nuclear receptor engineering based on novel structure activity relationships revealed by farnesyl pyrophosphate.

Protein engineering, design & selection : PEDS - 1 Nov 2010

Goyanka Ritu, Das Sharmistha, Samuels Herbert H, Cardozo Timothy

Abstract excerpt

Nuclear receptors (NRs) comprise the second largest protein family targeted by currently available drugs, acting via specific ligand interactions within the ligand binding domain (LBD). Recently, farnesyl pyrophosphate (FPP) was shown to be a unique promiscuous NR ligand, activating a subset of NR family members and inhibiting wound healing in skin. The current study aimed at visualizing the unique basis of FPP...

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Identifiers

PMID: 20817759
DOI: 10.1093/protein/gzq056
PMCID: PMC2953956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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