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Article

NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses.

Nature chemical biology - 1 Apr 2008

Nettles Kendall W, Bruning John B, Gil German, Nowak Jason, Sharma Sanjay K, Hahm Johnnie B, Kulp Kristen, Hochberg Richard B, Zhou Haibing, Katzenellenbogen John A, Katzenellenbogen Benita S, Kim Younchang, Joachmiak Andrzej, Greene Geoffrey L

Abstract excerpt

Our understanding of how steroid hormones regulate physiological functions has been significantly advanced by structural biology approaches. However, progress has been hampered by misfolding of the ligand binding domains in heterologous expression systems and by conformational flexibility that in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18344977
DOI: 10.1038/nchembio.76
PMCID: PMC2659626

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18344977-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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