Article
Isolation and characterization of fluorescence-enhancing RNA tags.
Bioorganic & medicinal chemistry - 1 Feb 2011
Wiesmayr Anna, Jäschke Andres
Abstract excerpt
Methods for the visualization of RNAs are urgently needed for studying a wide variety of cellular processes. Here we report on-bead screening of RNA libraries and its application to the isolation of specific fluorescence-enhancing RNA sequences. A one-bead-one-compound combinatorial RNA library with over one million different sequences was synthesized using the split-and-mix method. Solid-phase synthesis of 30...
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