Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Validation of a flow cytometry‐based detection of γ‐H2AX, to measure DNA damage for clinical applications

10 Apr 2016

Abstract excerpt

BACKGROUND: The nucleosomal histone protein H2AX is specifically phosphorylated (γ-H2AX) adjacent to DNA double-strand breaks (DSBs) and is used for quantifying DSBs. Many chemotherapies and ionizing radiation (IR) used in cancer treatment result in DSBs. Therefore, γ-H2AX has a significant potential as a biomarker in evaluating patient sensitivity and responsiveness to IR and chemotherapy. METHODS: Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27060560
DOI: 10.1002/cyto.b.21374

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Validation of a flow cytometry‐based detection of γ‐H2AX, to measure DNA damage for clinical applicationsPMID 27060560Read ↗

Development of a high-throughput γ-H2AX assay based on imaging flow cytometrySemantic proximity Read ↗

Factors to Consider for the Correct Use of γH2AX in the Evaluation of DNA Double-Strand Breaks Damage Caused by Ionizing RadiationSemantic proximity Read ↗

Differential DNA Damage Response of Peripheral Blood Lymphocyte Populations.Semantic proximity Read ↗

H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer TherapySemantic proximity Read ↗

Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay.Semantic proximity Read ↗

H2AX phosphorylation screen of cells from radiosensitive cancer patients reveals a novel DNA double-strand break repair cellular phenotype.Semantic proximity Read ↗

Genome Instability and γH2AX.Semantic proximity Read ↗

Histone γH2AX and Poly(ADP-Ribose) as Clinical Pharmacodynamic BiomarkersSemantic proximity Read ↗

A rapid flow cytometry test based on histone H2AX phosphorylation for the sensitive and specific diagnosis of ataxia telangiectasiaSemantic proximity Read ↗

DNA double-strand break repair capacity and normal tissue toxicity induced by radiotherapySemantic proximity Read ↗

γH2AX as a marker of DNA double strand breaks and genomic instability in human population studiesSemantic proximity Read ↗

DNA Repair and Cell Cycle Biomarkers of Radiation Exposure and Inflammation Stress in Human BloodSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.