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Article

Nitric oxide generation in children with malaria and the NOS2G-954C promoter polymorphism.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Nov 2010

Planche Timothy, Macallan Derek C, Sobande Toni, Borrmann Steffen, Kun Jürgen F J, Krishna Sanjeev, Kremsner Peter G

Abstract excerpt

Previous epidemiological studies have demonstrated a protective association between the NOS2G-954C (NOS2(Lambaréné)) polymorphism in inducible nitric oxide synthase and severe malaria. The polymorphism is commoner in children with uncomplicated compared with severe malaria. We now show that the likely mechanism for such protection is increased flux of nitrogen from arginine to nitric oxide (NO) during episodes of...

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Source

Identifiers

PMID: 20811009
DOI: 10.1152/ajpregu.00390.2010

Genes

NOS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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