Article
Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes.
Human genetics - 1 Feb 2010
Levesque Marc C, Hobbs Maurine R, O'Loughlin Charles W, Chancellor Jennifer A, Chen Youwei, Tkachuk Ariana N, Booth Jennifer, Patch Kistie B, Allgood Sallie, Pole Ann R, Fernandez Carolyn A, Mwaikambo Esther D, Mutabingwa Theonest K, Fried Michal, Sorensen Bess, Duffy Patrick E, Granger Donald L, Anstey Nicholas M, Weinberg J Brice
Abstract excerpt
Nitric oxide (NO) mediates host resistance to severe malaria and other infectious diseases. NO production and mononuclear cell expression of the NO producing enzyme-inducible nitric oxide synthase (NOS2) have been associated with protection from severe falciparum malaria. The purpose of this study was to identify single nucleotide polymorphisms (SNPs) and haplotypes in the NOS2 promoter, to identify associations...
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