Article
Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population.
The American journal of tropical medicine and hygiene - 1 Dec 2003
Boutlis Craig S, Hobbs Maurine R, Marsh Robyn L, Misukonis Mary A, Tkachuk Ariana N, Lagog Moses, Booth Jennifer, Granger Donald L, Bockarie Moses J, Mgone Charles S, Levesque Marc C, Weinberg J Brice, Anstey Nicholas M
Abstract excerpt
Polymorphisms in the inducible nitric oxide synthase gene (NOS2) promoter have been associated with clinical outcome from malaria. These include a CCTTT repeat (CCTTTn) 2.5 kilobases upstream from the NOS2 transcription start site, and two single nucleotide substitutions: G-->C at position -954 (...
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