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Article

NOS2 variants reveal a dual genetic control of nitric oxide levels, susceptibility to Plasmodium infection, and cerebral malaria.

Infection and immunity - 1 Mar 2014

Trovoada Maria de Jesus, Martins Madalena, Ben Mansour Riadh, Sambo Maria do Rosário, Fernandes Ana B, Antunes Gonçalves Lígia, Borja Artur, Moya Roni, Almeida Paulo, Costa João, Marques Isabel, Macedo M Paula, Coutinho António, Narum David L, Penha-Gonçalves Carlos

Abstract excerpt

Nitric oxide (NO) is a proposed component of malaria pathogenesis, and the inducible nitric oxide synthase gene (NOS2) has been associated to malaria susceptibility. We analyzed the role of NOS2 polymorphisms on NO bioavailability and on susceptibility to infection, Plasmodium carrier status and clinical malaria. Two distinct West African sample collections were studied: a population-based collection of 1,168...

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Identifiers

PMID: 24379293
DOI: 10.1128/IAI.01070-13
PMCID: PMC3958015

Genes

NOS2

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