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Article

Secretory sphingomyelinase in health and disease.

Biological chemistry - 1 Jun 2015

Kornhuber Johannes, Rhein Cosima, Müller Christian P, Mühle Christiane

Abstract excerpt

Acid sphingomyelinase (ASM), a key enzyme in sphingolipid metabolism, hydrolyzes sphingomyelin to ceramide and phosphorylcholine. In mammals, the expression of a single gene, SMPD1, results in two forms of the enzyme that differ in several characteristics. Lysosomal ASM (L-ASM) is located within the lysosome, requires no additional Zn2+ ions for activation and is glycosylated mainly with high-mannose...

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Source

Identifiers

PMID: 25803076
DOI: 10.1515/hsz-2015-0109

Genes

SMPD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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