Article
N-glycosylation of human sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is essential for stability, secretion and activity.
The Biochemical journal - 8 Mar 2017
Traini Mathew, Kumaran Raani, Thaysen-Andersen Morten, Kockx Maaike, Jessup Wendy, Kritharides Leonard
Abstract excerpt
Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a recently identified phosphodiesterase, which is a secreted N-linked glycoprotein. SMPDL3A is highly homologous to acid sphingomyelinase (aSMase), but unlike aSMase cannot cleave sphingomyelin. Rather, SMPDL3A hydrolyzes nucleotide tri- and diphosphates and their derivatives. While recent structural studies have shed light on these unexpected substrate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.