Secretion of acid Sphingomyelinase is affected by its polymorphic signal peptide.

doi:10.1159/000366345

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Article

Secretion of acid Sphingomyelinase is affected by its polymorphic signal peptide.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2014

Rhein Cosima, Reichel Martin, Mühle Christiane, Rotter Andrea, Schwab Sibylle G, Kornhuber Johannes

Abstract excerpt

BACKGROUND: Acid sphingomyelinase (ASM) catalyses the hydrolysis of sphingomyelin into ceramide, which acts as a lipid messenger that regulates important cellular functions. Deregulated ASM activity has been reported for different common diseases, but the mechanisms regulating ASM activity are still debated. ASM contains an exceptional signal peptide which is polymorphic due to a variable number of a...

Topics

Alleles
Cells, Cultured
Humans
Polymorphism, Genetic
Protein Sorting Signals
Sphingomyelin Phosphodiesterase
Tumor Necrosis Factor-alpha

Source

Open in PubMed

Identifiers

PMID: 25301364
DOI: 10.1159/000366345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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