Article
Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2001
Birbes H, El Bawab S, Hannun Y A, Obeid L M
Abstract excerpt
Our previous results have indicated that the major cellular pool of sphingomyelin present on the outer leaflet of the plasma membrane is not involved in the ceramide pathway of apoptosis. Thus, in this study we aimed at defining which intracellular pools of sphingomyelin and ceramide are involved in cell death. The bacterial sphingomyelinase (SMase) gene fused with green fluorescent protein was subcloned into...
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