Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of nucleophosmin/B23 in radiation-induced chromosomal instability in human lymphoblastoid cells of different p53 genotypes.

International journal of radiation biology - 1 Dec 2010

Chen Honghong, Jia Rongfei, Zhou Meijun, Xu Aihong, Hu Yuxing, Cheng Wenying, Shao Chunlin

Abstract excerpt

PURPOSE: To investigate the role of nucleophosmin (NPM/B23) in radiation-induced chromosomal instability and apoptosis in human lymphoblastoid cells with different protein 53 (p53) status. MATERIALS AND METHODS: Wild type (wt) p53 TK6 and mutant type (mt) p53 WTK1 with or without short hairpin RNA (shRNA)-mediated silencing of NPM, TK6 with or without short interfering RNA (siRNA)-mediated silencing of p53 (p53i...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Chromosomal Instability

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosome Aberrations

Share to Gamma Rays

Share to Lymphocytes

Share to Nucleophosmin

Share to Polyploidy

Share to RNA, Small Interfering

Source

Identifiers

PMID: 20807181
DOI: 10.3109/09553002.2010.501843

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of nucleophosmin/B23 in radiation-induced chromosomal instability in human lymphoblastoid cells of different p53 genotypes.PMID 20807181Read ↗

Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival.Semantic proximity Read ↗

A possible role for centrosome overduplication in radiation-induced cell death.Semantic proximity Read ↗

Different TP53 mutations are associated with specific chromosomal rearrangements, telomere length changes, and remodeling of the nuclear architecture of telomeres.Semantic proximity Read ↗

Nucleophosmin/B23 (NPM) oligomer is a major and stable entity in HeLa cells.Semantic proximity Read ↗

Wild-type p53 reduces radiation hypermutability in p53-mutated human lymphoblast cells.Semantic proximity Read ↗

Berberine-induced apoptosis of human leukemia HL-60 cells is associated with down-regulation of nucleophosmin/B23 and telomerase activitySemantic proximity Read ↗

B23 and ARF: friends or foes?Semantic proximity Read ↗

The effects of NBS1 knockdown by small interfering RNA on the ionizing radiation-induced apoptosis in human lymphoblastoid cells with different p53 status.Semantic proximity Read ↗

Chromosome changes caused by alterations of p53 expression.Semantic proximity Read ↗

Role of p53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinoma.Semantic proximity Read ↗

hHR23B is required for genotoxic-specific activation of p53 and apoptosis.Semantic proximity Read ↗

Induction of multinucleation in oral squamous cell carcinoma tissue with mutated p53 surviving boron neutron capture therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.