Article
A possible role for centrosome overduplication in radiation-induced cell death.
Oncogene - 2 Nov 2000
Sato N, Mizumoto K, Nakamura M, Ueno H, Minamishima Y A, Farber J L, Tanaka M
Abstract excerpt
Radiotherapy plays a key role in the treatment of many tumors; however, the precise mechanisms responsible for radiation-induced cell death remain uncertain. We have reported previously that ionizing radiation induces centrosome overduplication in human tumor cells. The present study was designed to elucidate a possible link between centrosome dysregulation and radiation-induced cell death. Exposure to 10 Gy...
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