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Article

Role of p53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinoma.

Radiation oncology (London, England) - 11 Dec 2009

Fujita Yusei, Kato Itsuro, Iwai Soichi, Ono Koji, Suzuki Minoru, Sakurai Yoshinori, Ohnishi Ken, Ohnishi Takeo, Yura Yoshiaki

Abstract excerpt

BACKGROUND: Boron neutron capture therapy (BNCT) is a selective radiotherapy, being effective for the treatment of even advanced malignancies in head and neck regions as well as brain tumors and skin melanomas. To clarify the role of p53 gene, the effect of BNCT on oral squamous cell carcinoma (SCC) cells showing either wild- (SAS/neo) or mutant-type (SAS/mp53) p53 was examined. METHODS: Cells were exposed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20003329
DOI: 10.1186/1748-717X-4-63
PMCID: PMC2803486

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