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Article

hHR23B is required for genotoxic-specific activation of p53 and apoptosis.

Oncogene - 22 Feb 2007

Kaur M, Pop M, Shi D, Brignone C, Grossman S R

Abstract excerpt

Rad23 proteins function in both DNA repair and protein stability regulation. As ubiquitinated forms of p53 are stabilized after DNA damage in concert with p53 functional activation, and human Rad23 proteins (hHR23A and B) regulate p53 stability in unstressed cells, the role of hHR23B in post-genotoxin regulation of p53 was investigated. Depletion of hHR23B by specific short interfering RNA before genotoxic...

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Identifiers

PMID: 16924240
DOI: 10.1038/sj.onc.1209865
PMCID: PMC1804095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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