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Berberine-induced apoptosis of human leukemia HL-60 cells is associated with down-regulation of nucleophosmin/B23 and telomerase activity

11 Jun 1999

Abstract excerpt

The steady-state level of nucleophosmin/B23 mRNA decreased during berberine-induced (25 microg/ml, 24 to 96 hr) apoptosis of human leukemia HL-60 cells. A decline in telomerase activity was also observed in HL-60 cells treated with berberine. A stable clone of nucleophosmin/B23 overexpressed in HL-60 cells was selected and found to be less responsive to berberine-induced apoptosis. About 35% to 63% of control...

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PMID: 10362140
DOI: 10.1002/(sici)1097-0215(19990611)81:6<923::aid-ijc14>3.0.co;2-d

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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