Article
Detection of epidermal growth factor receptor T790M mutation in plasma DNA from patients refractory to epidermal growth factor receptor tyrosine kinase inhibitor.
Cancer science - 1 Sept 2013
Sakai Kazuko, Horiike Atsushi, Irwin Darryl L, Kudo Keita, Fujita Yoshihiko, Tanimoto Azusa, Sakatani Toshio, Saito Ryota, Kaburaki Kyohei, Yanagitani Noriko, Ohyanagi Fumiyoshi, Nishio Makoto, Nishio Kazuto
Abstract excerpt
A secondary epidermal growth factor receptor (EGFR) mutation, the substitution of threonine 790 with methionine (T790M), leads to acquired resistance to reversible EGFR-tyrosine kinase inhibitors (EGFR-TKIs). A non-invasive method for detecting T790M mutation would be desirable to direct patient treatment strategy. Plasma DNA samples were obtained after discontinuation of gefitinib or erlotinib in 75 patients...
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