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Article

Deciphering letermovir's mode of action and resistance mutation effects.

Antiviral research - 1 Dec 2025

Gourin C, Flores T, Lefèvre C, Alain S, Ligat G, Hantz S

Abstract excerpt

Human cytomegalovirus is an opportunistic pathogen responsible for severe infections in immunocompromised patients, the leading cause of congenital infections worldwide, and potentially implicated in carcinogenesis. The HCMV terminase complex (pUL56-pUL89-pUL51) has emerged as a key target for antiviral drug development. Letermovir, an antiviral agent targeting this complex, inhibits viral DNA packaging, but...

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PMID: 41067565
DOI: 10.1016/j.antiviral.2025.106289

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