Article
Isolation and characterization of the herpes simplex virus 1 terminase complex.
Journal of virology - 1 Jan 2014
Heming Jason D, Huffman Jamie B, Jones Lisa M, Homa Fred L
Abstract excerpt
During herpes simplex virus 1 (HSV-1) infection, empty procapsids are assembled and subsequently filled with the viral genome by means of a protein complex called the terminase, which is comprised of the HSV-1 UL15, UL28, and UL33 proteins. Biochemical studies of the terminase proteins have been hampered by the inability to purify the intact terminase complex. In this study, terminase complexes were isolated by...
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