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Article

The nuclease domain of the SPP1 packaging motor coordinates DNA cleavage and encapsidation.

Nucleic acids research - 7 Jan 2013

Cornilleau Charlène, Atmane Noureddine, Jacquet Eric, Smits Callum, Alonso Juan C, Tavares Paulo, Oliveira Leonor

Abstract excerpt

The large terminase subunit is a central component of the genome packaging motor from tailed bacteriophages and herpes viruses. This two-domain enzyme has an N-terminal ATPase activity that fuels DNA translocation during packaging and a C-terminal nuclease activity required for initiation and termination of the packaging cycle. Here, we report that bacteriophage SPP1 large terminase (gp2) is a metal-dependent...

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Identifiers

PMID: 23118480
DOI: 10.1093/nar/gks974
PMCID: PMC3592435

Genes

SPP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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