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Article

The human cytomegalovirus terminase complex as an antiviral target: a close-up view

18 Jan 2018

Abstract excerpt

Human cytomegalovirus (HCMV) is responsible for life-threatening infections in immunocompromised individuals and can cause serious congenital malformations. Available antivirals target the viral polymerase but are subject to cross-resistance and toxicity. New antivirals targeting other replication steps and inducing fewer adverse effects are therefore needed. During HCMV replication, DNA maturation and packaging...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29361041
DOI: 10.1093/femsre/fuy004

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