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Human cytomegalovirus terminase as a target for antiviral chemotherapy

1 Mar 2002

Abstract excerpt

Herpesviral DNA packaging is a complex process involving binding and cleavage of DNA containing the specific DNA-packaging motifs, pac1 and pac2, and packaging of the resulting unit-length genomes into preformed procapsids. This process is believed to be mediated by two packaging proteins, the terminase subunits. In the case of human cytomegalovirus the terminase consists of the proteins pUL56 and pUL89. While...

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PMID: 11921307
DOI: 10.1002/rmv.344

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