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Article

Key domains involved in the interaction and assembly of the HCMV terminase complex.

Scientific reports - 20 Nov 2025

Gourin C, Lefèvre C, Flores T, Couvreux A, Alain S, Ligat G, Hantz S

Abstract excerpt

Human cytomegalovirus (HCMV) causes life-threatening infections, particularly in immunocompromised patients. Letermovir targets the viral terminase complex (pUL56, pUL89, pUL51), essential for DNA packaging, but resistance mutations in pUL56 underline the need for new antiviral strategies. Targeting critical interaction domains within the complex, such as the pUL56 peptide 671WMVVKYMGFF680, has emerged as a...

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Identifiers

PMID: 41266588
DOI: 10.1038/s41598-025-28915-5
PMCID: PMC12749448

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