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Article

Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients.

Annals of the rheumatic diseases - 1 Jan 2011

Coulthard Lydia R, Taylor John C, Eyre Steve, Robinson James I, Wilson Anthony G, Isaacs John D, Hyrich Kimme, Emery Paul, Barton Anne, Barrett Jennifer H, Morgan Ann W, McDermott Michael F

Abstract excerpt

BACKGROUND: Rheumatoid arthritis (RA) does not always respond to available treatments, including tumour necrosis factor (TNF) antagonists. A study was undertaken to investigate whether genetic variation within genes, encoding proteins in the p38 signalling network, contributes to the variable response to TNF antagonists. METHODS: 1102 UK Caucasian patients with RA receiving anti-TNF therapy (infliximab,...

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Share to Adalimumab
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20805296
DOI: 10.1136/ard.2010.133249

Genes

TNF
MAPK14
MAPKAPK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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