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Article

Pathway analysis to identify genetic variants associated with efficacy of adalimumab in rheumatoid arthritis.

Pharmacogenomics - 1 Jul 2017

Eektimmerman Frank, Swen Jesse J, Böhringer Stefan, Huizinga Tom Wj, Kooloos Wouter M, Allaart Cornelia F, Guchelaar Henk-Jan

Abstract excerpt

AIM: About 30% of rheumatoid arthritis patients have no clinical benefit from TNF inhibitors. Genome-wide association (GWA) and candidate gene studies tested several putative genetic variants for TNF inhibitor efficacy with inconclusive results. Therefore, this study applied a systematic pathway analysis. PATIENTS & METHODS: A total of 325 rheumatoid arthritis patients treated with adalimumab were genotyped for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arthritis, Rheumatoid

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Source

Identifiers

PMID: 28639493
DOI: 10.2217/pgs-2017-0047

Genes

TANK
TNF
TNFAIP3
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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