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Article

Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma.

Nature immunology - 1 Oct 2010

Lajoie Stephane, Lewkowich Ian P, Suzuki Yusuke, Clark Jennifer R, Sproles Alyssa A, Dienger Krista, Budelsky Alison L, Wills-Karp Marsha

Abstract excerpt

Severe asthma is associated with the production of interleukin 17A (IL-17A). The exact role of IL-17A in severe asthma and the factors that drive its production are unknown. Here we demonstrate that IL-17A mediated severe airway hyperresponsiveness (AHR) in susceptible strains of mice by enhancin...

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Identifiers

PMID: 20802484
DOI: 10.1038/ni.1926
PMCID: PMC2943538

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AHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20802484-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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