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Article

Regulation of Notch signalling by non-visual beta-arrestin.

Nature cell biology - 1 Dec 2005

Mukherjee Ashim, Veraksa Alexey, Bauer Andreas, Rosse Carine, Camonis Jacques, Artavanis-Tsakonas Spyros

Abstract excerpt

Signalling activity of the Notch receptor, which plays a fundamental role in metazoan cell fate determination, is controlled at multiple levels. We uncovered a Notch signal-controlling mechanism that depends on the ability of the non-visual beta-arrestin, Kurtz (Krz), to influence the degradation and, consequently, the function of the Notch receptor. We identified Krz as a binding partner of a known Notch-pathway...

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PMID: 16284625
DOI: 10.1038/ncb1327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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