Article
Overlapping roles of Drosophila Drak and Rok kinases in epithelial tissue morphogenesis.
Molecular biology of the cell - 15 Aug 2010
Neubueser Dagmar, Hipfner David R
Abstract excerpt
Dynamic regulation of cytoskeletal contractility through phosphorylation of the nonmuscle Myosin-II regulatory light chain (MRLC) provides an essential source of tension for shaping epithelial tissues. Rho GTPase and its effector kinase ROCK have been implicated in regulating MRLC phosphorylation in vivo, but evidence suggests that other mechanisms must be involved. Here, we report the identification of a single...
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