Article
New results of hemoglobin variant structure determinations by fast atom bombardment mass spectrometry.
Hemoglobin - 1 Jan 1990
Lacombe C, Promé D, Blouquit Y, Bardakdjian J, Arous N, Mrad A, Promé J C, Rosa J
Abstract excerpt
Fast atom bombardment mass spectrometry has already been used for the identification of mutations in abnormal human hemoglobin chains. This paper presents new results obtained with this technique. The methodology used here is compared with more conventional biochemical techniques and automated microsequencing. In every case, a well-chosen combination of peptide-high performance liquid chromatography, mass...
Topics
- Adult
- Amino Acid Sequence
- Female
- Hemoglobins, Abnormal
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Spectrometry, Mass, Fast Atom Bombardment