Article

The <i>In Vivo</i> Source of Type I and Type III IFNs is Pathogen Dependent

2021-10-05

Abstract excerpt

Type I (-α, β) and type III (-λ) interferons (IFNs) are produced in response to virus infection and upregulate a largely overlapping set of IFN stimulated genes which mediate the protective effects of these antiviral cytokines. In vitro studies have demonstrated the redundancy of these two cytokine families which activate the same transcription factor, IFN stimulated gene factor 3 (ISGF3), via distinct ligands an...

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Literature Corpus work: 427e69cd-be56-5ec1-b273-39841969c88a
DOI: 10.1101/2021.10.05.463160

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