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Article

HAND1 loss-of-function mutation associated with familial dilated cardiomyopathy.

Clinical chemistry and laboratory medicine - 1 Jul 2016

Zhou Yi-Meng, Dai Xiao-Yong, Qiu Xing-Biao, Yuan Fang, Li Ruo-Gu, Xu Ying-Jia, Qu Xin-Kai, Huang Ri-Tai, Xue Song, Yang Yi-Qing

Abstract excerpt

BACKGROUND: The basic helix-loop-helix transcription factor HAND1 is essential for cardiac development and structural remodeling, and mutations in HAND1 have been causally linked to various congenital heart diseases. However, whether genetically compromised HAND1 predisposes to dilated cardiomyopathy (DCM) in humans remains unknown. METHODS: The whole coding region and splicing junctions of the HAND1 gene were...

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Source

Identifiers

PMID: 26581070
DOI: 10.1515/cclm-2015-0766

Genes

HAND1
GATA4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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