Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery.

Molecular and cellular biology - 1 Nov 2010

Mao Xianrong R, Crowder C Michael

Abstract excerpt

Prolonged cellular hypoxia results in energy failure and ultimately cell death. However, less-severe hypoxia can induce a cytoprotective response termed hypoxic preconditioning (HP). The unfolded protein response pathway (UPR) has been known for some time to respond to hypoxia and regulate hypoxic sensitivity; however, the role of the UPR, if any, in HP essentially has been unexplored. We have shown previously...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Caenorhabditis elegans Proteins

Share to Genes, Helminth

Share to Hypoxia

Share to Protein Folding

Share to Tunicamycin

Share to Unfolded Protein Response

Source

Open in PubMed Open full text

Identifiers

PMID: 20733002
DOI: 10.1128/MCB.00922-10
PMCID: PMC2953055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery.PMID 20733002Read ↗

Hijacking Cellular Stress Responses to Promote LifespanSemantic proximity Read ↗

The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway.Semantic proximity Read ↗

Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors.Semantic proximity Read ↗

Age‐dependent heat shock hormesis to HSF ‐1 deficiency suggests a compensatory mechanism mediated by the unfolded protein response and innate immunity in young Caenorhabditis elegansSemantic proximity Read ↗

FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenationSemantic proximity Read ↗

Intracellular Signaling by the Unfolded Protein ResponseSemantic proximity Read ↗

Survival from hypoxia in C. elegans by inactivation of aminoacyl-tRNA synthetases.Semantic proximity Read ↗

Unfolded proteins in the mitochondria activate HRI and shut-down of mitochondrial protein translationSemantic proximity Read ↗

A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response.Semantic proximity Read ↗

Reprograming gene expression in “hibernating” <i>C. elegans</i> involves the IRE-1/XBP-1 pathwaySemantic proximity Read ↗

Crosstalk in oxygen homeostasis networks: SKN-1/NRF inhibits the HIF-1 hypoxia-inducible factor in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Autophagy protects against hypoxic injury in C. elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.