Article
Dominant lethal effects of nocodazole in germ cells of male mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Mar 2015
Attia S M, Ahmad S F, Okash R M, Bakheet S A
Abstract excerpt
The ability of the anticancer drug, nocodazole, to induce dominant lethal mutations in male germ cells was investigated by the in vivo dominant lethal test. Mice were treated with single doses of 15, 30 and 60 mg/kg nocodazole. These males were mated at weekly intervals to virgin females for 6 weeks. Nocodazole clearly induced dominant lethal mutations in the early spermatid stage with the highest tested dose....
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