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Article

A new dominant peroxiredoxin allele identified by whole-genome re-sequencing of random mutagenized yeast causes oxidant-resistance and premature aging.

Aging - 1 Aug 2010

Timmermann Bernd, Jarolim Stefanie, Russmayer Hannes, Kerick Martin, Michel Steve, Krüger Antje, Bluemlein Katharina, Laun Peter, Grillari Johannes, Lehrach Hans, Breitenbach Michael, Ralser Markus

Abstract excerpt

The combination of functional genomics with next generation sequencing facilitates new experimental strategies for addressing complex biological phenomena. Here, we report the identification of a gain-of-function allele of peroxiredoxin (thioredoxin peroxidase, Tsa1p) via whole-genome re-sequencing of a dominantSaccharomyces cerevisiae mutant obtained by chemical mutagenesis. Yeast strain K6001, a screening...

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Identifiers

PMID: 20729566
DOI: 10.18632/aging.100187
PMCID: PMC2954039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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