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Article

Effects of risk genes on BOLD activation in presymptomatic carriers of familial Alzheimer's disease mutations during a novelty encoding task.

Cerebral cortex (New York, N.Y. : 1991) - 1 Apr 2011

Ringman John M, Medina Luis D, Braskie Meredith, Rodriguez-Agudelo Yaneth, Geschwind Daniel H, Macias-Islas Miguel A, Cummings Jeffrey L, Bookheimer Susan

Abstract excerpt

Prior functional magnetic resonance imaging (fMRI) studies have found increased activity-related blood oxygen level-dependent (BOLD) signal in cognitively normal persons at genetic risk for Alzheimer's disease (AD). This has been interpreted as a compensatory response to incipient AD pathology. W...

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Identifiers

PMID: 20729396
DOI: 10.1093/cercor/bhq158
PMCID: PMC3059887

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20729396-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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