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Article

fMRI activation during episodic encoding and metacognitive appraisal across the lifespan: risk factors for Alzheimer's disease.

Neuropsychologia - 1 Jan 2008

Trivedi Mehul A, Schmitz Taylor W, Ries Michele L, Hess Timothy M, Fitzgerald Michele E, Atwood Craig S, Rowley Howard A, Asthana Sanjay, Sager Mark A, Johnson Sterling C

Abstract excerpt

In the present study, we used fMRI to examine the influence of age on two other known risk factors for Alzheimer's disease (AD), APOE genotype and parental history of AD (FH status), during episodic encoding (ENC) and metacognitive self-appraisal (SA) paradigms. These paradigms have previously been shown to evoke activity from brain regions that are implicated in AD. First we examined the effect of age across the...

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Identifiers

PMID: 18241895
DOI: 10.1016/j.neuropsychologia.2007.11.035
PMCID: PMC2443867

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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