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Article

Effect of Alzheimer disease risk on brain function during self-appraisal in healthy middle-aged adults.

Archives of general psychiatry - 1 Oct 2007

Johnson Sterling C, Ries Michele L, Hess Timothy M, Carlsson Cynthia M, Gleason Carey E, Alexander Andrew L, Rowley Howard A, Asthana Sanjay, Sager Mark A

Abstract excerpt

CONTEXT: Asymptomatic middle-aged adult children of patients with Alzheimer disease (AD) recently were found to exhibit functional magnetic resonance imaging (fMRI) deficits in the mesial temporal lobe during an encoding task. Whether this effect will be observed on other fMRI tasks is yet unknown. This study examines the neural substrates of self-appraisal (SA) in persons at risk for AD. Accurate appraisal of...

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Identifiers

PMID: 17909128
DOI: 10.1001/archpsyc.64.10.1163
PMCID: PMC2650497

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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