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Article

Serotonin transporter gene, stress and raphe-raphe interactions: a molecular mechanism of depression.

Trends in neurosciences - 1 Jul 2012

Jasinska Agnes J, Lowry Christopher A, Burmeister Margit

Abstract excerpt

Reports of gene-environment interactions (GxE) between the serotonin transporter gene and stress on risk of depression have generated both excitement and controversy. The controversy persists in part because a mechanistic account of this GxE on serotonergic neurotransmission and risk of depression has been lacking. In this Opinion, we draw on recent discoveries in the functional neuroanatomy of the serotonergic...

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PMID: 22301434
DOI: 10.1016/j.tins.2012.01.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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