Article
Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1.
Brain : a journal of neurology - 1 Sept 2010
Costigan Michael, Belfer Inna, Griffin Robert S, Dai Feng, Barrett Lee B, Coppola Giovanni, Wu Tianxia, Kiselycznyk Carly, Poddar Minakshi, Lu Yan, Diatchenko Luda, Smith Shad, Cobos Enrique J, Zaykin Dmitri, Allchorne Andrew, Gershon Edith, Livneh Jessica, Shen Pei-Hong, Nikolajsen Lone, Karppinen Jaro, Männikkö Minna, Kelempisioti Anthi, Goldman David, Maixner William, Geschwind Daniel H, Max Mitchell B, Seltzer Ze'ev, Woolf Clifford J
Abstract excerpt
Not all patients with nerve injury develop neuropathic pain. The extent of nerve damage and age at the time of injury are two of the few risk factors identified to date. In addition, preclinical studies show that neuropathic pain variance is heritable. To define such factors further, we performed a large-scale gene profiling experiment which plotted global expression changes in the rat dorsal root ganglion in...
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