Article
Analysis of a novel calcium auxotrophy in Aspergillus nidulans.
Fungal genetics and biology : FG & B - 1 Jul 2010
Findon Helen, Calcagno-Pizarelli Ana-Maria, Martínez José L, Spielvogel Anja, Markina-Iñarrairaegui Ane, Indrakumar Tanya, Ramos José, Peñalva Miguel A, Espeso Eduardo A, Arst Herbert N
Abstract excerpt
In Aspergillus nidulans a combination of null mutations in halA, encoding a protein kinase, and sltA, encoding a zinc-finger transcription factor having no yeast homologues, results in an elevated calcium requirement ('calcium auxotrophy') without impairing net calcium uptake. sltA(-) (+/-halA(-)) mutations result in hypertrophy of the vacuolar system. In halA(-)sltA(-) (and sltA(-)) strains, transcript levels...
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