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Article

A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension.

Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2007

Xiang Minghui, Feng Mingye, Muend Sabina, Rao Rajini

Abstract excerpt

Phylogenetic analysis of the cation/proton antiporter superfamily has uncovered a previously unknown clade of genes in metazoan genomes, including two previously uncharacterized human isoforms, NHA1 and NHA2, found in tandem on human chromosome 4. The NHA (sodium hydrogen antiporter) family members share significant sequence similarity with Escherichia coli NhaA, including a conserved double aspartate motif in...

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Identifiers

PMID: 18000046
DOI: 10.1073/pnas.0707120104
PMCID: PMC2141836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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