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Article

PAI-1 4G/5G polymorphism contributes to cancer susceptibility: evidence from meta-analysis.

PloS one - 1 Jan 2013

Wang Shangqian, Cao Qiang, Wang Xiaoxiang, Li Bingjie, Tang Min, Yuan Wanqing, Fang Jianzheng, Qian Jian, Qin Chao, Zhang Wei

Abstract excerpt

BACKGROUND: The plasminogen activator inhibitor-1 (PAI-1) is expressed in many cancer cell types and allows the modulation of cancer growth, invasion and angiogenesis. To date, studies investigated the association between a functional polymorphism in PAI-1 (4G/5G) and risk of cancer have shown inclusive results. METHODS: A meta-analysis based on 25 case-control studies was performed to address this issue. Odds...

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Identifiers

PMID: 23437240
DOI: 10.1371/journal.pone.0056797
PMCID: PMC3577655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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