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Regulation of cell proliferation by the opioid growth factor receptor is dependent on karyopherin <i>β</i> and Ran for nucleocytoplasmic trafficking

1 Sept 2010

Abstract excerpt

The opioid growth factor (OGF; [Met(5)]-enkephalin) and the OGF receptor (OGFr) form an endogenous and tonically active growth-regulating system that modulates cell proliferation by upregulating the cyclin-dependent kinase inhibitory pathway. Previous reports have documented that nucleocytoplasmic trafficking of the OGF-OGFr axis is dependent on nuclear localization signals. This study determined the specific...

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PMID: 20705629
DOI: 10.1258/ebm.2010.010139

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