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The OGF-OGFr axis utilizes the p21 pathway to restrict progression of human pancreatic cancer

11 Jan 2008

Abstract excerpt

BACKGROUND: Pancreatic cancer is the 4th leading cause of death from cancer in the U.S. The opioid growth factor (OGF; [Met5]-enkephalin) and the OGF receptor form an inhibitory growth regulatory system involved in the pathogenesis and treatment of pancreatic cancer. The OGF-OGFr axis influences the G0/G1 phase of the cell cycle. In this investigation, we elucidate the pathway of OGF in the cell cycle. RESULTS:...

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PMID: 18190706
DOI: 10.1186/1476-4598-7-5

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